[Analysis of pediatric «short stays¼ in a second-level hospital throughout 25 years]. / Análisis de las «estancias cero¼ pediátricas en un hospital de nivel 2 a lo largo de 25 años.

INTRODUCTION: It is essential to admit patients to hospital in an efficient way in order to use resources rationally. Short hospitalary stays are hospitalizations which does not include 00:00h and are considered avoidable. This study describes trends and characteristics of short stays throughout 25 years in our hospital. PATIENTS AND METHODS: We analyzed hospital pediatric discharges in a second-level hospital through the registration system «conjunto mínimo básico de datos¼. We categorized pediatric patients and newborn patients in two groups according to length of hospital stay: «short stays¼ and «prolonged stays¼. We analyzed and compared the following variables: gender, age, type of admission, month, diagnosis-related groups (DRG) and admission service. Binary logistic regression analysis and assessment of trends through joinpoint regression analysis were performed. RESULTS: From 1993 to 2017, 45710 children were admitted to our hospital, of which 7.3% were short stays. The trend analysis showed a point of change upwards-downwards at the beginning of the millennium. Pediatric short stays: the most important variables were emergency admissions (89%), urgent transfers (9%), month December (11%) and main diagnosis category: nervous system (18%). Mean diagnosis-related groups cost was 2432±1115€ in short stays group and 2549±1065€ in prolonged stays. CONCLUSIONS: Short stays and prolonged stays show a falling trend in our hospital. Short stays percentage in our environment is similar to other neighbor countries. Some of our short stays are urgent transfers and admissions for clinical observation. We did not find clinical significance in weight or cost of pediatric patients' DRG comparing to prolonged stays.

Repercusión de la pandemia COVID-19 en la actividad pediátrica en Atención Primaria / Impact of the COVID-19 pandemic on the pediatric activity in Primary Care

Introducción. La pandemia por COVID-19 ha supuesto un cambio en nuestras vidas y deseamos conocer su influencia en las consultas de pediatría en Atención Primaria. Pacientes y métodos. Estudio observacional retrospectivo de la actividad en un Centro de Salud urbano entre enero 2019 y marzo 2021. Se realiza aleatorización estratificada para elegir semana y día y se incluyen todos los pacientes. La información se extrae del programa Medora. Se recogen las variables: fecha de consulta, fecha de nacimiento, profesional, sexo, patología crónica, tipo y motivo de consulta, hospitalización reciente y afectación por COVID-19. Se realiza un análisis de regresión logística binaria y análisis de regresión de joinpoint. Resultados. La muestra es de 1.802 consultas. La tendencia de las tasas de consultas es estable de forma global y en la atención de enfermería, pero hay cambios estacionales en la atención de los pediatras. Durante la pandemia el tipo de consulta a la demanda/urgencia ha sido inferior que la programada (Odds Ratio = 0,19, IC al 95%: 0,1 a 0,3) y la atención telefónica/no presencial superior a la programada (Odds Ratio = 4,01: IC95% 2,3 a 6,95). El comportamiento de las consultas por tipo de patologías, consulta de revisión, vacunaciones o aspectos administrativos ha sido similar antes y durante la pandemia. Conclusión. El volumen de atenciones en nuestro Centro de Salud ha sido similar durante el periodo estudiado. La atención telefónica/no presencial ha sido cuatro veces superior a la consulta programada. Existen diferencias estacionales con descenso estival (AU)

Introduction. Our aim is to know the impact of the pandemic on pediatric activity in Primary Care.Patients and methods. Retrospective observational study of pediatric activity in an urban Health Center between January 2019 and March 2021. Stratified randomization is performed to choose the week and day. All patients are included. The information collected is extracted from the Medora program. Date of consultation, date of birth, professional, sex, chronic pathology, type and reason for consultation, recent hospitalization and involvement by COVID-19 are collected. Binary logistic regression analysis and regression analysis of joinpoint are performed.Results. The sample is made up of 1802 consultations. Trend in consultation rates is stable globally and in nursing care, but there are seasonal changes in pediatric care. During the pandemic, the demand/urgent consultation was lower than scheduled (Odds Ratio = 0.19, 95% CI 0.1 to 0.3) and telephone/non-face-to-face consultations were higher than scheduled (Odds Ratio = 4.01: 95% CI 2.3 to 6.95). The behavior of consultations by type of pathology, review consultation, vaccinations or administrative aspects has been similar before and during the pandemic.Conclusion. The number of consultations in our Health Center has been similar along the studied period. Telephone/non-face-to-face assistance has been four times higher thanscheduled consultation. There are seasonal differences in pediatric care with a summer decline (AU)

A tough act to follow: collagen hydrogel modifications to improve mechanical and growth factor loading capabilities.

Collagen hydrogels are among â€‹the most well-studied platforms for drug delivery and in situ tissue engineering, thanks to their low cost, low immunogenicity, versatility, biocompatibility, and similarity to the natural extracellular matrix (ECM). Despite collagen being largely responsible for the tensile properties of native connective tissues, collagen hydrogels have relatively low mechanical properties in the absence of covalent cross-linking. This is particularly problematic when attempting to regenerate stiffer and stronger native tissues such as bone. Furthermore, in contrast to hydrogels based on ECM proteins such as fibronectin, collagen hydrogels do not have any growth factor (GF)-specific binding sites and often cannot sequester physiological (small) amounts of the protein. GF binding and in situ presentation are properties that can aid significantly in the tissue regeneration process by dictating cell fate without causing adverse effects such as malignant tumorigenic tissue growth. To alleviate these issues, researchers have developed several strategies to increase the mechanical properties of collagen hydrogels using physical or chemical modifications. This can expand the applicability of collagen hydrogels to tissues subject to a continuous load. GF delivery has also been explored, mathematically and experimentally, through the development of direct loading, chemical cross-linking, electrostatic interaction, and other carrier systems. This comprehensive article explores the ways in which these parameters, mechanical properties and GF delivery, have been optimized in collagen hydrogel systems â€‹and examines their in vitro or in vivo biological effect. This article can, therefore, be a useful tool to streamline future studies in the field, by pointing researchers into the appropriate direction according to their collagen hydrogel design requirements.

Resultado de la implantación de consultas telemáticas en cirugía ortopédica y traumatología durante la pandemia COVID-19 / Result of the implementation of telematic consultations in orthopaedic surgery and traumatology during COVID-19 laparoscopic surgery

La pandemia COVID ha hecho de las consultas telemáticas una herramienta básica en la práctica diaria. El objetivo principal del estudio es valorar los resultados de la aplicación de consultas telemáticas para limitar la movilidad de los pacientes. Son objetivos operativos: proponer un plan de consultas, conocer cómo limita la asistencia a las consultas, definir qué patologías se benefician más con este plan. MATERIAL Y MÉTODOS: Se propone un esquema con la creación de consultas previas a las agendadas para valorar idoneidad y posibilidad de realizarla en acto único no presencial. RESULTADOS: Se han realizado 5.619 consultas con una falta de respuesta telefónica del 19%. El 74% de los pacientes fueron resueltos de forma virtual. Existe diferencia entre unidades, siendo más probable la respuesta telefónica para las consultas de unidad, OR = 0,60 o de traumatología general, OR = 0,67 y menos para los derivados desde urgencias. El 20% de las consultas no se acompañaban de pruebas complementarias. Las consultas de traumatología general, OR = 0,34, control postoperatorio, OR = 0,49, y unidades, OR = 0,40, cumplieron mejor este requisito. De los pacientes restantes, las consultas de traumatología general, OR = 0,50, y las derivadas a unidades, OR = 0,54 fueron las que más se resolvieron sin acudir presencialmente. CONCLUSIONES: Se han resuelto de forma no presencial el 74% de los pacientes que atendieron a la llamada telefónica. El 20% de los pacientes acuden a la visita sin pruebas complementarias. Las consultas de seguimiento de osteosíntesis y postoperatorio de cirugía artroscópica son las que más precisan de ser realizadas de forma presencial

The COVID pandemic has made telematic consultations a basic tool in daily practice. AIMS: The main objective of the study is to assess the results of the application of telematic consultations to limit the mobility of patients. The operational objectives are; to propose a consultation plan, to know how attendance limits consultations and to define which pathologies benefit the most from this plan. METHODS: A scheme is proposed with the creation of pre-scheduled clinic to assess suitability and the possibility of carrying them out in a single non face-to-face act. RESULTS: Phone call to 5,619 patients were made with a lack of response of 19%. The cases of 74% of the patients that answered were resolved virtually. There is a difference between units, obtaining a higher answering rate from patients appointed to specific clinic units, OR = 0.60, or to general trauma ones, OR = 0.67. The lowest answering rate was obtained from those derived from the emergency department. Twenty per cent of the consultations were not accompanied by complementary tests that would have favored the resolution in a single act. The general trauma consultations, OR = 0.34, postoperative control, OR = 0.49, and specific unit ones, OR = 0.40, were the ones that better met this requirement. Out of the remaining patients, the general trauma consultations, OR = 0.50, and those referred to units, OR = 0.54, were the ones that had a higher resolution rate without in- person consultation. CONCLUSIONS: The cases of 74% of the patients who answered the phone call were resolved virtually. Cases of 20% of the patients cannot be solved in a single act because they are derived without complementary tests. Osteosynthesis and postoperative arthroscopic follow-up consultations are the ones that need to be carried out in person the most

Result of the implementation of telematic consultations in orthopaedic surgery and traumatology during COVID-19 laparoscopic surgery. / Resultado de la implantación de consultas telemáticas en cirugía ortopédica y traumatología durante la pandemia COVID-19.

The COVID pandemic has made telematic consultations a basic tool in daily practice. AIMS: The main objective of the study is to assess the results of the application of telematic consultations to limit the mobility of patients. The operational objectives are; to propose a consultation plan, to know how attendance limits consultations and to define which pathologies benefit the most from this plan. METHODS: A scheme is proposed with the creation of pre-scheduled clinic to assess suitability and the possibility of carrying them out in a single non face-to-face act. RESULTS: Phone call to 5,619 patients were made with a lack of response of 19%. The cases of 74% of the patients that answered were resolved virtually. There is a difference between units, obtaining a higher answering rate from patients appointed to specific clinic units, OR = 0.60, or to general trauma ones, OR = 0.67. The lowest answering rate was obtained from those derived from the emergency department. Twenty per cent of the consultations were not accompanied by complementary tests that would have favored the resolution in a single act. The general trauma consultations, OR = 0.34, postoperative control, OR = 0.49, and specific unit ones, OR = 0.40, were the ones that better met this requirement. Out of the remaining patients, the general trauma consultations, OR = 0.50, and those referred to units, OR = 0.54, were the ones that had a higher resolution rate without in- person consultation. CONCLUSIONS: The cases of 74% of the patients who answered the phone call were resolved virtually. Cases of 20% of the patients cannot be solved in a single act because they are derived without complementary tests. Osteosynthesis and postoperative arthroscopic follow-up consultations are the ones that need to be carried out in person the most.

Annual variations of total and fractionated chlorophyll and phytoplankton groups in the Gulf of Cadiz.

Chlorophyll and phytoplankton distribution and concentration in the Gulf of Cadiz were studied during 2014 and 2015. In both years the highest chlorophyll concentrations are found at coastal stations during spring. Pico- and nanophytoplankton are the main contributors to total chlorophyll, with highest concentrations at the outer limit of the continental shelf. Microphytoplankton is responsible for most of the inshore chlorophyll. Picophytoplankton was analyzed to determine density, biomass and distribution. Prochlorococcus and Synechococcus show differences in distribution depending on distance from the coast and depth. Our results suggest temperature and consequent water stratification seem to be the main factors determining deep fluorescence maxima (DFM), mainly formed by picophytoplankton, especially Prochlorococcus. Pigment identification assisted by CHEMTAX analysis was carried out to analyze relative concentrations of larger phytoplankton.

Aerotransporte de pacientes con alto riesgo de contaminación por enfermedad infecciosa, a propósito de tres casos / High risk infections patients Air Medevec. Our experience after 3 medical cases

Las tropas españolas destacadas en operaciones internacionales en áreas tropicales con enfermedades infecciosas emergentes pueden verse en situación de riesgo de contagio, a lo que se suma el potencial uso de armas biológicas en los actuales conflictos de guerra desigual. Este riesgo puede hacerse extensivo a toda la población bajo responsabilidad española. Esta situación hizo que la Sanidad Militar Española y, en el caso que se presenta, la Unidad Médica de Aeroevacuación (UMAER) actualizase sus procedimientos de defensa NBQ en vigor desde el inicio de las misiones de las Fuerzas Armadas en territorio africano. Se reforzó la respuesta a la amenaza biológica en dichos ambientes tropicales y se trabajó y entrenó en la posibilidad de transporte aéreo de pacientes con enfermedades infecciosas transmisibles para su tratamiento definitivo en territorio nacional. Este artículo es un informe de lo sucedido durante estas misiones. Es un reconocimiento a todas las personas involucradas y sus esfuerzos

Spanish troops deployed on international operations all over African tropical areas can be exposed to high-risk situations due to severe infectious diseases that can affect the population under their responsibility as well as to the possible use of biological weapons in current international conflicts. In this situation the Spanish Unified Defense Medical Command and, in this particular case, the Spanish Unit Medical Evacuation (UMAER) updated their NBC defense procedures since the beginning of these missions of Spanish armed forces in Africa. Initially the response capability to this biological threat was reinforced in these territories, and afterwards training was carried out for the possibility of MEDEVAC missions of patients with infectious diseases in order to receive definitive treatment on national territory. This article is a report of what happened during these missions. It is recognition of all people involved and their efforts

Homogeneous Diffusion Solid Model as a Realistic Approach to Describe Adsorption onto Materials with Different Geometries.

In this work, the adsorption kinetics of p-nitrophenol (PNP) onto several commercial activated carbons (ACs) with different textural and geometrical characteristics was studied. For this aim, a homogeneous diffusion solid model (HDSM) was used, which does take the adsorbent shape into account. The HDSM was solved by means of the finite element method (FEM) using the commercial software COMSOL. The different kinetic patterns observed in the experiments carried out can be described by the developed model, which shows that the sharp drop of adsorption rate observed in some samples is caused by the formation of a concentration wave. The model allows one to visualize the changes in concentration taking place in both liquid and solid phases, which enables us to link the kinetic behaviour with the main features of the carbon samples.

Aeroevacuación médica táctica y estratégica de la fuerza desplegada en Afganistán / Tactical and strategic air evacuation of the military deployed in Afghanistan

Desde el inicio del trabajo de nuestras Fuerzas Armadas en Afganistán en 2002, hasta la actualidad, muchos efectivos han sido desplegados en esta Zona de Operaciones. La cadena logística sanitaria diseñada para el apoyo sanitario a la Fuerza desplegada tiene una clara misión, procurar a los heridos una asistencia sanitaria tan eficaz como la que se dispone en Territorio Nacional y una vez estabilizados solicitar su evacuación médica, que continúe y adelante los cuidados en ruta para un tratamiento definitivo en nuestro País. Esta responsabilidad corresponde a la Unidad Médica de Aeroevacuación, del Ejército del Aire. En un estudio descriptivo y retrospectivo del archivo de la unidad, se analizan las evacuaciones realizadas con origen en Afganistán, en cuanto a la naturaleza de las lesiones, los medios aéreos empleados y los recursos humanos y materiales que se implican en cada misión encomendada

Since the beginning of the Spanish Military deployment in Afghanistan in the year 2002 to the present, many troops have been deployed in the Operations Theatre. It has been designed a medical-supply chain to support the contingents, whose main aim is to provide the injured people with medical assistance as efficient as it is in their home country. Once those injured people have been stabilized, an AeroMedical evacuation is needed to take them to a role 4 facility for the definitive treatment. In this Aeromedical Evacuation the treatment should be continued or even have the possibility of start a new one. The MedEvac responsibility relays on the Aeromedical Evacuation Unit (UMAER). Aeromedical evacuations preformed from Afghanistan have been reviewed in a descriptive and retrospective study using the unite archives. In this study we analyze the wounds nature, aeronautical assets that have been employed and the material and human resources used in every mission

Utilización de la monitorización analgésica intraoperatoria mediante pupilometría en el consumo de analgésicos durante las primeras 12 horas del postoperatorio / The use of pupillometry as monitoring of intraoperative analgesia in the consumption of analgesics during the first 12 hours after surgery

Introducción. Habitualmente, la analgesia intraoperatoria se controla empíricamente con base en las variaciones hemodinámicas del paciente. Un manejo incorrecto durante este proceso puede incrementar la morbimortalidad quirúrgica y también el dolor agudo postoperatorio. El objetivo de este estudio fue valorar si la monitorización intraoperatoria de la analgesia mediante pupilometría tenía algún efecto sobre la intensidad del dolor y el consumo de analgésicos en planta, en las primeras 12 h del postoperatorio de cirugía mayor ginecológica. Pacientes y métodos. Estudio de cohortes, prospectivo con asignación de grupos de forma secuencial según programación de quirófano. Pacientes ASA I-III sometidas a cirugía electiva de histerectomía abdominal por laparotomía o laparoscopia mediante anestesia general intravenosa. Los grupos de estudio fueron: grupo pupilometría (P-1), cuya analgesia intraoperatoria se monitorizó mediante pupilómetro, y grupo hemodinámico (H-2), a partir de valores de presión arterial y frecuencia cardíaca. En la sala de hospitalización se registraron rutinariamente los valores de la escala visual analógica (EVA) con 3 cortes para el estudio: a las 3, 8 y 12 h del postoperatorio. Según protocolo se administró un analgésico si la EVA era ≥ 3 o si la paciente lo solicitaba expresamente. A posteriori, se valoró la eficacia del tratamiento y si continuaba con dolor se prescribía el siguiente fármaco pautado hasta conseguir una EVA < 3. Se controló el consumo de analgésicos administrados en las 12 h del postoperatorio en planta y se registró cualquier incidencia o efectos adversos relacionados con el estudio. Resultados. Fueron incluidas 59 pacientes: 30 en el grupo P-1 y 29 en el grupo H-2. El grupo P-1 experimentó menos dolor que el grupo H-2, con una significación estadística en cada una de las fases (EVA 3 h, EVA 8 h y EVA 12 h). Se observó una diferencia estadísticamente significativa (p < 0,001) en la media (DE) del número de fármacos analgésicos empleados por paciente entre el grupo P-1 (1,80 [0,99]; mediana 2, intervalo de confianza 95% 1,43-2,17) y el grupo H-2 (5,66 [1,58]; mediana 6, intervalo de confianza 95% 5,05-6,26). Conclusiones. La monitorización de la analgesia intraoperatoria mediante pupilometría resultó un método simple y fiable que consiguió reducir la intensidad del dolor y el consumo de analgésicos en planta las primeras 12 h del postoperatorio tras cirugía mayor ginecológica (AU)

Introduction. Intraoperative evaluation of analgesia remains today often based on heart rate and arterial pressure fluctuations. None of these parameters is specific. Incorrect handling during this process may increase surgical morbi-mortality of the patients and their acute postoperative pain. The aim of this study was to evaluate the impact of intraoperative analgesia controlled by pupillometry on postoperative analgesic consumption and the pain intensity in the first 12 h in the hospital room, after major gynecological surgery. Patients and methods. A prospective, cohort study with allocation of groups of sequentially according to programming of operating room was designed. ASA I-III patients scheduled for elective surgery of abdominal hysterectomy by laparotomy or laparoscopy through intravenous general anesthesia were included. Patients were divided into 2 groups: pupillometry group (P-1), in which intraoperative analgesia was guided by pupillometry, and hemodynamic group (H-2) according to values of blood pressure and heart rate. In the hospitalization room the values of visual analogue scale (VAS) were routinely registered with 3 courts for the study: 3, 8 and 12 h of the postoperative period. Postoperative analgesia was standardized as follows: NSAIDs was administered if VAS was ≥ 3 or if the patient expressly requested an analgesic. After this, the efficacy of treatment was assessed. If the patient had pain, the next scheduled drug was given up to an VAS < 3. Data for total analgesic consumption administered in the hospital room, VAS and adverse effects were collected within 12 h postoperatively. Results. A total of 59 patients, 30 group P-1 and 29 group H-2, were included. Group P-1 experienced less pain than group H-2, with statistical significance in each phase (VAS 3 h, VAS 8 h and VAS 12 h). These data are consistent with the consumption of analgesics for patients. There was a statistically significant reduction (p < 0.001) in the group P-1 (1.80 [DE 0.99]; medium 2, 95% confidence interval 1.43-2.17) compared with group H-2 (5.66 [1.58]; medium 6, 95% confidence interval 5.05-6.26). Conclusions. Monitoring of the intraoperative analgesia by pupillometry was able to reduce the intensity of the acute postoperative pain and analgesic consumption in the first 12 h in the hospital room after major gynecological surgery (AU)

The use of pupillometry as monitoring of intraoperative analgesia in the consumption of analgesics during the first 12 hours after surgery.

INTRODUCTION: Intraoperative evaluation of analgesia remains today often based on heart rate and arterial pressure fluctuations. None of these parameters is specific. Incorrect handling during this process may increase surgical morbi-mortality of the patients and their acute postoperative pain. The aim of this study was to evaluate the impact of intraoperative analgesia controlled by pupillometry on postoperative analgesic consumption and the pain intensity in the first 12h in the hospital room, after major gynecological surgery. PATIENTS AND METHODS: A prospective, cohort study with allocation of groups of sequentially according to programming of operating room was designed. ASA I-III patients scheduled for elective surgery of abdominal hysterectomy by laparotomy or laparoscopy through intravenous general anesthesia were included. Patients were divided into 2 groups: pupillometry group (P-1), in which intraoperative analgesia was guided by pupillometry, and hemodynamic group (H-2) according to values of blood pressure and heart rate. In the hospitalization room the values of visual analogue scale (VAS) were routinely registered with 3 courts for the study: 3, 8 and 12h of the postoperative period. Postoperative analgesia was standardized as follows: NSAIDs was administered if VAS was ≥ 3 or if the patient expressly requested an analgesic. After this, the efficacy of treatment was assessed. If the patient had pain, the next scheduled drug was given up to an VAS<3. Data for total analgesic consumption administered in the hospital room, VAS and adverse effects were collected within 12h postoperatively. RESULTS: A total of 59 patients, 30 group P-1 and 29 group H-2, were included. Group P-1 experienced less pain than group H-2, with statistical significance in each phase (VAS 3h, VAS 8h and VAS 12h). These data are consistent with the consumption of analgesics for patients. There was a statistically significant reduction (p<0.001) in the group P-1 (1.80 [DE 0.99]; medium 2, 95% confidence interval 1.43-2.17) compared with group H-2 (5.66 [1.58]; medium 6, 95% confidence interval 5.05-6.26). CONCLUSIONS: Monitoring of the intraoperative analgesia by pupillometry was able to reduce the intensity of the acute postoperative pain and analgesic consumption in the first 12h in the hospital room after major gynecological surgery.

Sobre el triaje telefónico / No disponible

No disponible

[Functional magnetic resonance imaging: a critical analysis of its technical, statistical and theoretical implications in human neuroscience]. / Resonancia magnética funcional: análisis crítico de sus implicaciones técnicas, estadísticas y teóricas en neurociencia humana.

INTRODUCTION: The use of functional magnetic resonance imaging (fMRI) has represented an important step forward for the neurosciences. Nevertheless, it has also been subject to rather a lot of criticism. AIM: To study the most widespread criticism against fMRI, so that researchers who are starting to use it may know the different elements that must be taken into account to be able to take a suitable approach to this technique. DEVELOPMENT: The fact that fMRI allows brain activity to be observed makes it a very attractive and useful tool, and its use has grown exponentially since the last decade of the 20th century. At the same time, criticism against its use has become especially fierce. Most of this scepticism can be classified into aspects related with the technique and physiology, the analysis of data and their theoretical interpretation. In this study we will review the main arguments defended in each of these three areas, as well as looking at whether they are well-founded or not. Additionally, this work is also intended as a reference for novel researchers when it comes to identifying elements that must be taken into account as they approach fMRI. CONCLUSIONS: Despite the fact that fMRI is one of the most interesting options for observing the brain available today, its correct utilisation requires a great deal of control and knowledge. Even so, today most of the criticism it receives no longer has any solid foundation on which to stand.

TITLE: Resonancia magnetica funcional: analisis critico de sus implicaciones tecnicas, estadisticas y teoricas en neurociencia humana.Introduccion. La utilizacion de la resonancia magnetica funcional (RMf) ha supuesto una gran revolucion en el avance de las neurociencias. Pese a ello, ha sido objeto de numerosas criticas. Objetivo. Estudiar las criticas mas generalizadas hacia la RMf, de manera que investigadores que se inicien en su uso conozcan los diferentes elementos que hay que tener en cuenta para un acercamiento adecuado a esta tecnica. Desarrollo. Su gran atractivo y utilidad a la hora de observar la actividad cerebral han hecho de la RMf una tecnica cuyo uso ha crecido exponencialmente desde la ultima decada del siglo XX. Paralelamente, la critica hacia ella ha sido especialmente feroz. La mayoria de este escepticismo puede clasificarse en aspectos concernientes a la tecnica y fisiologia, el analisis de los datos y su interpretacion teorica. Mediante este trabajo se revisaran los principales argumentos en cada uno de estos tres apartados, asi como su adecuacion. Adicionalmente, se pretende que este trabajo pueda servir de referencia para investigadores noveles a la hora de identificar elementos que se deban tener en cuenta en su acercamiento a la RMf. Conclusion. Pese a que la RMf constituye actualmente una de las opciones mas interesantes para observar el cerebro, es necesario un alto grado de control y conocimiento para su utilizacion. Aun asi, gran parte de las criticas no se sostiene hoy en dia.

Linfoma cutáneo primario difuso de células grandes-tipo pierna con regresión espontánea / Spontaneous Regression of Primary Diffuse Large B-Cell Lymphoma, Leg Type

El linfoma cutáneo primario difuso de células grandes-tipo pierna (LCPDCG-TP) representa aproximadamente el 20% de los linfomas cutáneos primarios de células B y suele presentarse como nódulos, tumores y placas infiltradas en las extremidades inferiores en las últimas etapas de la vida. A diferencia de otras entidades de este grupo se caracteriza por un pobre pronóstico, que suele requerir el uso de tratamiento quimioterápico sistémico. Presentamos el caso de una paciente de 82 años con nódulos y placas en el miembro inferior derecho de un año de evolución, que fueron biopsiadas llegándose al diagnóstico de LCPDCG-TP y presentando, un mes después de la primera visita, resolución espontánea de las lesiones sin tratamiento. Se trata de un caso con un desarrollo atípico, siendo el primero publicado en la literatura con dicha evolución

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT) accounts for approximately 20% of all primary cutaneous B-cell lymphomas and tends to present as infiltrated nodules, tumors, and plaques on the legs in the elderly. Unlike other primary cutaneous large B-cell lymphomas, it has a poor prognosis and tends to require treatment with systemic chemotherapy. We present the case of an 82-year-old patient with a 1-year history of nodules and plaques on her right leg. Biopsy led to a diagnosis of PCLBCL LT and the lesions resolved without treatment within 1 month of the first visit. This is an atypical course of PCLBCL LT and we believe that it is the first such case to be reported in the literature

Spontaneous regression of primary diffuse large B-cell lymphoma, leg type.

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT) accounts for approximately 20% of all primary cutaneous B-cell lymphomas and tends to present as infiltrated nodules, tumors, and plaques on the legs in the elderly. Unlike other primary cutaneous large B-cell lymphomas, it has a poor prognosis and tends to require treatment with systemic chemotherapy. We present the case of an 82-year-old patient with a 1-year history of nodules and plaques on her right leg. Biopsy led to a diagnosis of PCLBCL LT and the lesions resolved without treatment within 1 month of the first visit. This is an atypical course of PCLBCL LT and we believe that it is the first such case to be reported in the literature.

Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis.

BACKGROUND AND PURPOSE: PDE4 inhibition suppresses experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). However, side effects hinder PDE4 inhibitors clinical use. PDE7 inhibition might constitute an alternative therapeutic strategy, but few data about the anti-inflammatory potential of PDE7 inhibitors are currently available. We have used the EAE model to perform a comparative evaluation of PDE4 and PDE7 inhibition as strategies for MS treatment. EXPERIMENTAL APPROACH: Two PDE7 inhibitors, the sulfonamide derivative BRL50481 and the recently described quinazoline compound TC3.6, were assayed to modulate EAE in SJL mice, in comparison with the well-known PDE4 inhibitor Rolipram. We evaluated clinical signs, presence of inflammatory infiltrates in CNS and anti-inflammatory markers. We also analysed the effect of these inhibitors on the inflammatory profile of spleen cells in vitro. KEY RESULTS: TC3.6 prevented EAE with efficacy similar to Rolipram, while BRL50481 had no effect on the disease. Differences between both PDE7 inhibitors are discussed. Data from Rolipram and TC3.6 showed that PDE4 and PDE7 inhibition work through both common and distinct pathways. Rolipram administration caused an increase in IL-10 and IL-27 expression which was not found after TC3.6 treatment. On the other hand, both inhibitors reduced IL-17 levels, prevented infiltration in CNS and increased the expression of the T regulator cell marker Foxp3. CONCLUSIONS AND IMPLICATIONS: These results provide new information about the effects of Rolipram on EAE, underline PDE7 inhibition as a new therapeutic target for inflammatory diseases and show the value of TC3.6 to prevent EAE, with possible consequences for new therapeutic tools in MS.

Eosinophilic pustular folliculitis in infancy: report of a new case.

We report a new case of eosinophilic pustular folliculitis in a 23-month-old boy. He presented with a seven-month history of recurrent episodes of pustular lesions on the scalp after having been treated with oral antifungal and topic antibiotics without response. The diagnosis was based on the clinical course and typical histopathological findings. Eosinophilic pustular folliculitis in infancy is an idiopathic and rare inflammatory disease characterized by recurrent crops of sterile pustules involving mainly the scalp. Because it is a benign, self-limiting condition an accurate diagnosis is essential to avoid unnecessary therapies.

Índice de masa corporal y aumento de peso en el embarazo. Resultado obstétrico de la inducción de parto / Body mass index and gestational weight gain. Pregnancy outcomes after labor induction

Objetivo: Determinar el resultado de la inducción de parto en función del índice de masa corporal (IMC) materno y del aumento de peso en el embarazo en el Hospital de León en el periodo enero-marzo de 2008.Material y método Estudio de cohortes prospectivo. Analizamos 127inducciones de parto. Incluimos las variables: causa de la inducción, procedimientos de maduración cervical e inducción empleados, edad materna al fin de la gestación, tipo de parto, paridad, test de Bishop inicial, IMC, peso, talla, incremento ponderal durante la gestación, peso del recién nacido y test de Apgar al primer y quinto minuto. Resultados Se realizó inducción en el 21,3% de los partos del periodo. En el 81,1% se consiguió parto vaginal. El 36,2% de las pacientes tenía sobrepeso, el 21,2% obesidad y el 4,7% obesidad mórbida. Conclusiones Se encontraron relaciones no significativas entre el fracaso de la inducción con el IMC (p=0,08) y con el aumento de peso (p=0,07), incrementando el porcentaje de partos por cesárea (AU)

Objective: To determine the obstetric results of labor induction in relation to body mass index(BMI) and gestational weight gain at the Leon Hospital between January and March, 2008.Material and method: We conducted a prospective cohort study of 127 labor inductions. The variables included were the medical reason for induction, the procedures employed for cervical ripening and induction, maternal age at the end of pregnancy, type of labor, parity, initial Bishop’s score, BMI, weight, height, gestational weight gain, neonatal weight and Apgar test at1 and 5 minutes. Results Inductions were performed in 21.3% of births, while vaginal delivery was achievedin 81.1%. A total of 36.2% of the patients were overweight, 21.2% were obese and 4.7% were morbidly obese. Conclusions: A non-statistically significant association was observed between failure of vaginal delivery and BMI (P = .08) and body weight gain (P = .07). These two variables seem to increase the chances of failure of cervical ripening and induction of labor, increasing the percentage of cesarean sections (AU)